Saint Sebastian in a Rocky Landscape with Saints Jerome, Anthony Abbot and Christopher

Marco Zoppo's Saint Sebastian in a Rocky Landscape with Saints Jerome, Anthony Abbot, and Christopher from 1476 is among his most ambitious multi-saint compositions, grouping four major devotional figures within a single rocky landscape — a format that was standard in Venetian and mainland Italian altarpiece production. Sebastian was invoked against plague; Jerome was the patron of scholars; Anthony Abbot was the protector against epidemic disease and the patron of swineherds; Christopher was invoked for protection during travel. The combination of Sebastian and Anthony Abbot — both plague saints — in a single panel may indicate this was a votive commission during or following a plague episode. Zoppo's treatment of the rocky landscape as an almost architecturally structured space reflects his training in Padua, where Mantegna's geological fantasy landscapes had been established as a model.

Zoppo distributes the four saints across the rocky landscape setting with careful attention to spatial intervals and sightlines between figures. Sebastian's bound and pierced body occupies a central position, allowing the characteristic anatomical display — ribcage, shoulder articulation, the arrows' specific angles — that made the saint's image one of the most technically demanding in the devotional repertoire. The landscape's interlocking rock formations create a backdrop of angular grey-blue forms.