Saint Anne with the Virgin and Child, Saint James the Great and Saint Roch as Intercessors for Mankind Ridden by the Plague

Painted around 1515 , this devotional work by Niklaus Manuel demonstrates the sixteenth-century approach to sacred subjects, balancing theological orthodoxy with artistic innovation. Painted at the height of the High Renaissance, the work draws on centuries of iconographic tradition while expressing Niklaus Manuel's individual interpretation of the divine narrative. The early sixteenth century marked the summit of Renaissance art, as Leonardo, Michelangelo, and Raphael achieved a classical perfection of form that would influence European painting for centuries.

The devotional work is executed with skilled technique, reflecting Niklaus Manuel's engagement with the demands of religious painting. The composition balances narrative clarity with spiritual atmosphere, using careful observation to heighten the sacred drama.